Calyculin A

Catalog #:

IN0042

IN0042-25ug	USD159.0
IN0042-100ug	USD442.0

Synonyms: Calyculin A

IUPAC Name:

N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S, 9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-di hydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13 -tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-( phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-prope nyl]-2-oxazoly]butyl]-4-deoxy-4-(dimethylamino)-5- O-methyl-L-ribonamide

Functional Activity:

Calyculin A is a natural product originally isolated from the marine sponge Discodermia calyx. Calyculins have proven to be strong serine/threonine protein phosphatase inhibitors and based on this property, calyculins might be potential anticancer agents.

calyculin A is a potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC50 = 0.3 - 0.7 nM) and protein phosphatase 2A (IC50 = 0.5 - 1 nM). It displays > 10,000,000-fold selectivity over PP2B and PP2C.

Technical Data:

M.Wt: 1009.18

Formula: C₅₀H₈₁ N₄O₁₅P

Solubility: Soluble to 50 mM in DMSO

Purity: >97%

Storage: Dessicate at -20 degree C

CAS No.: 101932-71-2

Related Products by Target:

References for Calyculin A:

1. Dynia, D. W., Steinmetz, A. G., and Kocinsky, H. S. NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase. Am J Physiol Renal Physiol, 298: F745-753.

2. Inutsuka, A., Goda, M., and Fujiyoshi, Y. Calyculin A-induced neurite retraction is critically dependent on actomyosin activation but not on polymerization state of microtubules. Biochem Biophys Res Commun, 390: 1160-1166, 2009.

3. Goto, N. and Harayama, H. Calyculin A-sensitive protein phosphatases are involved in maintenance of progressive movement in mouse spermatozoa in vitro by suppression of autophosphorylation of protein kinase A. J Reprod Dev, 55: 327-334, 2009.

4. Goda, M., Inoue, S., and Mabuchi, I. Calyculin-A induces cleavage in a random plane in unfertilized sea urchin eggs. Biol Bull, 216: 40-44, 2009.

5. Bergs, J. W., Ten Cate, R., Rodermond, H. M., Jaarsma, P. A., Medema, J. P., Darroudi, F., Buist, M. R., Stalpers, L. J., Haveman, J., Van Bree, C., and Franken, N. A. Transient inhibition of Calyculin A induced premature chromosome condensation by hyperthermia. Int J Hyperthermia, 25: 220-228, 2009.

Certificate of Analysis/MSDS is available upon request with lot number