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ION CHANNELS/TRANSPORTERSIon channels help establish and control the small voltage gradient across the plasma membrane of cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells. They are present on all membranes of cell (plasma membrane) and intracellular organelles (nucleus, mitochondria, endoplasmic reticulum, golgi apparatus and so on). Such "multi-subunit" assemblies usually involve a circular arrangement of identical or homologous proteins closely packed around a water-filled pore through the plane of the membrane or lipid bilayer. Some channels permit the passage of ions based solely on their charge of positive (cation) or negative (anion).
Ion channels can be classified by different properties, including by the gating mechanism or the ion selectivity of the pore. Voltage-gated ion channels Ligand-gated ion channels (also known as ionotropic receptors) Light-gated ion channels Mechanosensitive ion channels Cyclic nucleotide-gated ion channels Calcium-gated ion channels Calcium Potassium Sodium Chloride Proton Non-selective (let any type of ion pass) There are a number of chemicals and genetic disorders which disrupt normal functioning of ion channels and have disastrous consequences for the organism. Genetic disorders of ion channels and their modifiers are known as channelopathies. |
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