GROWTH FACTOR RECEPTOR PATHWAYS (EGFR/HER/VEGFR/PDGFR/FGFR)

Growth factors and growth factor receptors play an important physiological role in the normal process of growth and differentiation. In a simplistic model, the binding of the growth factor to its receptor leads to receptor dimerization and cross phosphorylation, activating the receptors. The activated receptors phosphorylate a series of cytoplasmic proteins which in turn sets off a cascade of events leading to the activation of transcription factors in the nucleus, which then leads to increased mRNA synthesis. The translation of the mRNA results in increased protein synthesis finally leading to either growth or differentiation. The peptide and polypeptide growth factors, unlike classical hormones, are produced in a variety of tissues throughout the body and their action is not necessarily restricted to single tissue types. These factors can act by an intracrine, autocrine, juxtacrine, paracrine or endocrine process.

Products for Growth Factor Receptor Pathways (EGFR/HER/VEGFR/PDGFR/FGFR)