Spiperone

Catalog #:

IN0066

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IN0066-50mg

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Synonyms: Spiperone, 8-[3-(p-Fluorobenzoyl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, R 5147, Spiroperidol, Spiropitan

IUPAC Name:

8-[4-(4-fluorophenyl)-4-oxo-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

Functional Activity:

Spiperone is a psychoactive drug and research chemical belonging to the butyrophenone chemical class. It functions as a 5-HT1A, 5-HT2A, 5-HT7, and D2 receptor antagonist, and has been used to identify these receptors when labeled with tritium. It has negligible affinity for the 5-HT2C receptor. Additionally, spiperone was identified by compound screening to be an activator of Ca²⁺ activated Cl^- channels (CaCCs), thus a potential target for therapy of cystic fibrosis. It is also an α1B-adrenoceptor antagonist

Technical Data:

M.Wt: 395.47

Formula: C₂₃H₂₆ FN₃O₂

Solubility: Soluble in water, 0.2 mg/mL , soluble in 0.1M HCl, 0.5mg/mL, soluble in ethanol, 1.5mg/mL

Purity: >95%

Storage: Dessicate at RT

CAS No.: 749-02-0

Solutions may be stored for 1-2 days at 4°C.

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References for Spiperone:

1. Lu, D. and Carson, D. A. Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway. BMC Pharmacol, 9: 13, 2009.

2. Packeu, A., De Backer, J. P., and Vauquelin, G. Non-competitive interaction between raclopride and spiperone on human D-receptors in intact Chinese hamster ovary cells. Fundam Clin Pharmacol, 24: 283-291.

3. He, X., Xiao, L., and Sui, N. Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks. Eur J Pharmacol, 627: 136-141.

4. Liang, L., MacDonald, K., Schwiebert, E. M., Zeitlin, P. L., and Guggino, W. B. Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airway. Am J Physiol Cell Physiol, 296: C131-141, 2009.

Certificate of Analysis/MSDS is available upon request with lot number